Most of the pharmaceuticals are administered by the oral route which is the popular route of\ndrug delivery. Taste is an essential and critical parameter in administering formulations which\nhave relation with taste buds. Several drugs have bitter taste, consequently there is a consistent\nproblem in the treatment of the patients because of their inability to swallow such formulations.\nFour formulations of taste masked granules of clarithromycin were thus prepared by wet\ngranulation and enteric-coating techniques using different concentrations of taste masking agent\nand two coating materials. The resulting clarithromycin granules were characterized for size\ndistribution, content determination, dissolution at phosphate buffer (pH 6.8), release in 0.1N HCl\nand taste evaluation. Among these formulations, Formulation D showed minimum bitterness,\nbetter dissolution profile at phosphate buffer at pH 6.8 and higher resistance to the acidic\nmedium comparing to other formulations. The formulation D presented showed to be a good\nbase for preparing an oral reconstitutable suspension, which was evaluated for various parameters\nlike drug content, dissolution at phosphate buffer at pH 6.8 and taste evaluation. The oral taste\nmasked suspension prepared disposed respectable decline in the sour taste of clarithromycin and\nsimilar dissolution profile in comparison with marketed suspension.
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